Complex trait genetics

Genetic variations between individuals partially explain the varied physical differences within our population, or our risk of developing disease. The lab of Dr. Guillaume Lettre uses flow cytometry methods (pangenomic genotyping and second-generation sequencing) to identify the genes responsible for specific cardiovascular diseases (e.g., heart attack, dilated cardiomyopathy) or the genes that modify the clinical severity of these same diseases. We have recently developed bioinformatic, epigenomic and molecular/cellular approaches to characterize our genetic discoveries.