Molecular and Cellular Signalling
Terence Hébert
, Ph. D
Research in Dr. Hébert's laboratory
centers on the determination of the mechanisms controlling
specificity of signalling in cardiac cells.
Cells must discriminate among a plethora of signals and in many
instances must be able to integrate signals coming from several
different pathways. Thus, the cell must simultaneously facilitate
this crosstalk between receptor pathways and paradoxically limit it
in order to preserve specificity. The problem of specificity in
GPCR signalling becomes apparent when one considers that there are
hundreds of different receptors, 16 G protein a subunits, 5 Gb
subunits and 12 Gg subunits as well as a large number of effectors
and regulatory proteins. Our hypothesis is that the different
signalling molecules form pre-assembled complexes which assure
specificity and speed of response in the various pathways. These
complexes and the interfaces between the different partners could
be the targets for more effective therapeutic strategies.
Our long term goal is the development of drugs possessing much
fewer side effects for the treatment of various cardiovascular
diseases.
Publications
Rebois, R.V.,
Hébert, T.E.
Protein complexes involved in signal transduction
mediated by heptahelical receptors,
Receptors and Channels, 9 pages 169 à
194, 2003
Mirshahi, T., Robillard, L., Zhang, H.,
Hébert, T.E., Logothetis, D.E.
G
b
residues that do not interact with Ga underlie agonist-independent
activity of K + channels,
J. Biol.Chem., 277, pages 7348 à 7355,
2002.
Lavoie, C., Mercier, J.-F., Salahpour, A., Umapathy, D., Breit,
A. Villeneuve, L.-R., Zhu, W.-Z., Lakatta, E.G., Xiao, R.P.,
Bouvier, M.,
Hébert, T.E.
b
1/
b
2-adrenergic receptor hetero-dimerization regulates
b
2-adrenergic receptor internalization and ERK signalling
efficacy,
J. Biol. Chem., 277 pages 35402 à
35410, 2002
Lavine, N., Ethier, N., Oak, J.N., Pei, L., Liu, F., Trieu, P.,
Rebois, R.V., Bouvier, M.,
Hébert, T.E. and Van Tol,
H.H.M. (2002)
Receptor/effector interactions in G protein-coupled receptor
systems,
J. Biol. Chem., 277 pages 46010 à
46019, 2002
