Cardiologie d'intervention
Luc Bilodeau
, M.D
My research team's particular interests include
clinical research, animal modelization and biomaterial
development in interventional cardiology. Global work
aims at searching for new applications, technique refinement and
implantation of new concepts for minimally invasive percutaneous
treatment of coronary disease, valvulopathy, peripheral vascular
disease and cardiac failure.
Actually we are working at refining coated and
covered stents to prevent restenosis. We have a
research program in gene therapy for refractory
angina. We elaborate in conjunction with the medical
devices industry a new generation of excimer laser to treat
totally occluded arteries. We are also working at
developing percutaneous mitral annuloplasty.
Book Chapters
Bilodeau L, Tanguay JF, Sirois M. Restenosis in
peripheral intervention. In. R.R. Heuser and M. Henry. Textbook
of Peripheral Vascular Interventions. Martin Dunitz, Taylor &
Francis Group plc. United Kingdom. 475-484 – 2003
Thierry B,
Bilodeau L, Tabrizian M. STENTS
Encyclopedia of Biomaterials and Biomedical Engineering
D0I:10.1081/E-EBBE 120005525.pages 1403-1411.
Published Articles
Thierry B, Merhi Y,
Bilodeau L, Trépanier C, Tabrizian M.
(2002) Nitinol Versus Stainless Steel Stents : Acute
thrombogenicity Study in an Ex vivo Porcine Model. Biomaterials,
23:2997-3005.
Tuinenburg JC, Koning G, Hekking E, Desjardins C, Harel F,
Bilodeau L, van Weert AW, Lespérance
J, Reiber JHC JH. One core laboratory at two
international sites, is that feasible? An inter-core laboratory
and intra-observer variability study. Catheter Cardiovasc Interv.
2002 Jul;56(3):333-340.
Thierry B, Merhi Y, Trépanier C,
Bilodeau L, Yahia L'H, Tabrizian M. (2002) Blood
compatibility of Nitinol compared to Stainless Steel.
SMST Proc, 285-290.
Stone GW, Cox DA, Babb J, Nukta D,
Bilodeau L, Cannon L, Stuckey TD, Hermiller J,
Cohen EA, Low R, Bailey SR, Lansky AJ, Kuntz RE. Prospective,
randomized evaluation of thrombectomy prior to percutaneous
intervention in diseased saphenous vein grafts and thrombus
containing coronary arteries. J Am Coll Cardiol. 2003 Dec 3;
42(11):2007-13.
Bilodeau L, Fretz E B, Taeymans Y, Koolen J,
Taylor K, Hilton D J. Novel use of a high energy
excimer laser catheter for calcified and complex coronary artery
lesions. Catheter Cardiovasc Inter. Catheter
Cardiovasc Interv 2004;62 :155-161.
Perrault LP, Jeanmart H,
Bilodeau L, Lesperance J, Tanguay JF, Bouchard
D, Page P, Carrier M. Early quantitative coronary
angiography of sapheneous vein grafts for coronary artery bypass
grafting harvested by means of open versus endoscopic
saphenectomy: A prospective randomized
trial. J Thorac Cardiovasc Surg 2004
May;127(5):1402-7.
Fort S, Silber S, Lewis BS, Kornowski R,
Bilodeau L, Almagor Y, van Remortel E, Morice
MC, Colombo A. “Fused-Gold” vs.
“Bare” Stainless Steel NIRflex Stents of
the Same Geometric Design in Diseased Native Coronary Arteries
– Long term Results from the NIR TOP
Study. Submitted to Am J Cardiol (04-11-02).
Tanabe K, Serruys PW, Degertekin M, Guagliumi G, Grube E,
Chan C, Munzel T, Belardi J, Ruzyllo W,
Bilodeau L, Kelback H, Ormiston J, Dwakins K,
Roy L, Strauss BH, Disco C, Koglin J, Russell ME. Chronic
Arterial Responses to Polymer Controlled Paclitaxel-Eluting
Stents. Circulation. 2004;109:196-200
Thierry B. Kujama P, Tkaczyk C, Winnik FM,
Bilodeau L, Tabrizian M. Delivery
Plateform for Hydrophobic Drugs: Prodrug Approach
Combined with Self-Assembled Multilayers. J Am Chem
S Accepted for publication.
Awaida JPS, Dupuis J, Théroux P, Pelletier G.,
Joyal M, deGuise P, Doucet S.,
Bilodeau L, Thibault B, Tanguay JF, Gallo R.
Grégoire J, L'Allier P, Macle M, Nigam A.
Demographics, treatment and outcome of acute coronary
syndromes: 17 years of experience in a specialized
cardiac centre. (Submitted to CMAJ).
Fort S, Silber S, Lewis BS, Kornowski R,
Bilodeau L, Almagor Y, van Remortel E, Morice
MC, Colombo A. Fused-gold vs. bare stainless steel
NIRflex Stents of the same geometric design in diseased native
coronary arteries – Long term result from the NIR TOP
study. Am J Cardiol. (submitted November
2004).
Ly H, Awaida JPS, Lespérance J,
Bilodeau L. Angiographic and
Clinical Outcomes of polytetrafluoroethylene-covered stent use in
significant coronary perforations. Am J Cardiol
2005;95:244-246.
Abstracts
Perrault L,
Bilodeau L, Lespérance J, Tanguay JF,
Bouchard D, Pagé P, Carrier M. A prospective
Randomized Angiographic Study of Open Versus Endoscopic
Saphenectomy for CABG. Can. J Cardiol. Oct 2002: Abstract 191.
Thierry B, Merhi Y,
Bilodeau L, Winnik F, Tabrizian M.
“Polysaccharide Nanoscale Autoassembly on Injured
Arteries”, ESB, September 2002, Spain.
Perrault LP,
Bilodeau L, Jeanmart H, Lespérance J,
Tanguay JF, Bouchard D, Pagé P, Carrier M. A
prospective Randomized Angiographic Study of Open Versus
Endoscopic Saphenectomy for CABG. Heart Surg Forum 6
(Suppl 1):S48,2003.
Jeanmart H, Perrault LP,
Bilodeau L, Lespérance J, Tanguay JF,
Bouchard D, Pagé P, Carrier M.
Quantitative Coronary Angiography of Saphenous Vein Grafts for
CABG Harvested by Open Versus Endoscopic Saphenectomy. Can J
Cardiol 19 (Suppl A)132A:2003: Abstract 2181.
Jeanmart H, Perrault LP,
Bilodeau L, Lespérance J, Tanguay JF,
Bouchard D, Pagé P, Carrier M.
Quantitative Coronary Angiography of Saphenous Vein Grafts for
CABG Harvested by Open Versus Endoscopic Saphenectomy, Research
Day, Montreal Heart Institute, June 2003.
Jeanmart H, Perrault LP,
Bilodeau L, Lespérance J, Tanguay JF,
Bouchard D, Pagé P, Carrier M.
Quantitative coronary angiography of sapheneous vein grafts for
coronary artery bypass graft harvested by open versus endoscopic
saphenectomy. Clin Sci (Suppl IV) :IV-657, 2003
Jeanmart H, Perrault LP,
Bilodeau L, Lespérance J, Tanguay JF,
Bouchard D, Pagé P, Carrier M.
Quantitative coronary angiography of sapheneous vein grafts for
coronary artery bypass graft harvested by open versus endoscopic
saphenectomy Circulation 108 (Suppl IV):IV-627, 2003.
Lasic Z, Mehran R, Nikolsky E, Negoita M, Costa R, Cox DA,
Babb J, Nukta D,
Bilodeau L, Cannon L, Stuckey TD, Hermiller J,
Lansky A, Leon MB, Stone GW. Lennox Hill Hospital, New York City,
NY. Implications and prevention of large periprocedural
myocardial infarction after percutaneous intervention of diseased
saphenous vein grafts and thrombotic native coronary
lesions. J Am Coll Cardiol 2004. Abstract
(88-A)1155-78, Suppl A, (43).
Thierry B, Winnik F, Merhi Y,
Bilodeau L, Tabrizian M. “Non-Viral
transfection of the vasculature though self-assembled
nanocoatings”, WBC, May 2004, Australia.
Wacinski P,
Bilodeau L, Crépeau J, deGuise P,
Gallo R, Ibrahim R, Joyal M, L'Allier P, Tanguay JF, Doucet
S. Drug Eluting Stents in complex coronary
lesions. Comparison of Sirolimus (Cypher) and
Paclitaxel (Taxus) Stents in Clinical Practice.
Single Center experience. Munich, ESC 2004. European
Heart Journal
Wacinski P,
Bilodeau L, Gallo R, Tanguay JF, Ibrahim R,
L'Allier P, Crépeau J, Doucet
S. Are drug eluting stents an alternative for CABG in
patients with multivessel coronary artery disease or left main
lesion? Single center experience.
Washington, TCT 2004. Am J Cardiol (TCT-469, p. 216E)
Wacinski P,
Bilodeau L, Crépeau J, Gallo R,
Ibrahim R, Tanguay JF, Doucet S. Excimer laser 0,9 mm
catheter for calcified uncrossable coronary lesions.
Washington, TCT 2004. Am J Cardiol (TCT-92, p.42E)
Wacinski P,
Bilodeau L, Gallo R, Ibrahim R,
Crépeau J, Joyal M, deGuise P, Doucet S.
Drug eluting stents in complex coronary lesion.
Comparison of Sirolimus (Cypher) and Paclitaxel (Taxus) stents in
clinical practice. Washington, TCT 2004.
Am J Cardiol (TCT-285, p. 133E)
Awaida JP, Dupuis J, Théroux P, Joyal M, deGuise
P, Doucet S,
Bilodeau L, Tanguay JF, Gallo R,
Grégoire J, L'Allier P, Macle L.
Demographics, treatment and outcome of acute coronary
syndromes: 17 years of experience in a tertiary care
centre. CCS-2004 Can J Cardiol; Vol 20,
Suppl. D, page 124D # 316.
Ly HQ, Awaida JP, Lespérance J,
Bilodeau L. Angiographic and
clinical outcomes of PTFE-covered stent use in PCI-related
significant coronary perforations. CCS-2004 Can J
Cardiol; Vol 20, Suppl. D, page 193D # 577.
Ramanathan K, Cantor WJ, Nguyen CM, Buller CE, Webb J,
Bilodeau L, Farkouh ME, Tmychak W, Labinaz M,
Fitchett D, Hochman JS, Dzavik V. High rates of
persistent cardiogenic shock despite re-establishing patency of
the infarct-related artery: A report from the Shock-2
screening log registry. CCS-2004 Can J Cardiol; Vol
20, Suppl. D, page 194D # 580.
