Prevention of progression and regression of
atherosclerosis
Jean-Claude Tardif
, M.D.
Dr. Jean-Claude Tardif's research is directed
towards the development of new therapies that will stop
progression or induce regression of atherosclerosis.
Atherosclerosis is the leading cause of death
worldwide. The working hypothesis is that atherosclerosis is a
chronic inflammatory disease mediated partly by oxidative stress
and that anti-inflammatory therapies and/or anti-oxidants as well
as modulators of lipid metabolism will permit to stabilize or
even regress the disease.
Our laboratory uses different imaging techniques of
atherosclerosis and of the endothelium such as intravascular
ultrasound (IVUS), computer-assisted quantitative analysis of
coronary angiograms (QCA), magnetic resonance imaging (MRI) and
image fusion. We also work on the development and validation of
other biomarkers related to cardiovascular diseases.
The ultimate goal is to prevent the morbidity and
mortality related to atherosclerosis. Until now, the findings of
Dr. Tardif's team led to the creation of new pharmacological
approaches and new technologies which are currently being studied
in large clinical trials.
Publications
Tardif JC, Côté G,
Lespérance J, et al. Probucol and multivitamins in the
prevention of restenosis after coronary angioplasty. N Engl J Med
1997;337:365-372.
Rodés J,
Tardif JC, Lespérance J, et al.
Prevention of restenosis after angioplasty in small coronary
arteries with probucol. Circulation 1998;97:429-436.
Côté G,
Tardif JC, Lespérance J, et al.
Effects of probucol on vascular remodeling after coronary
angioplasty. Circulation 1999;99:30-35.
Tardif JC, Bourassa MG. Antioxidants and
cardiovascular disease. Tardif JC, Bourassa MG, eds.
Kluwer Publishers, 2000, pp 1-250.
Tardif JC, Grégoire J, Schwartz L,
Title L, Laramée L, Reeves F, Lespérance J,
Bourassa MG, L'Allier PL, Lambert J, Guertin MC, for the Canadian
Antioxidant Restenosis Trial (CART-1) Investigators. Effects of
AGI-1067 and probucol after percutaneous coronary interventions.
Circulation 2003; 107:552-558.
