Cardiac Remodelling
Angelino Calderone
, Ph. D.
The primary objective is to elucidate the
molecular and cellular events associated with the development of
cardiac hypertrophy and scar formation post myocardial infarction.
We have identified the presence of neural stem cells in the infarct
region of the damaged rat heart. The physiological role of neural
stem cells in scar formations remains to be
determined.
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Nguyen QT, Colombo F, Clement R, Rouleau JL,
Calderone A. AT1 receptor antagonist therapy
preferentially ameliorated right ventricular function and
phenotype during the early phase of remodeling post-MI.
British Journal of Pharmacology
2003;138:1485-1494.
Drapeau J, El-Helou V, Clement R, Bel-Hadj
S, Gosselin H, Trudeau LE, Villeneuve L,
Calderone A. Nestin-expressing neural
stem cells identified in the scar following myocardial
infarction. J Cell Physiol. 2004 Dec 16; [Epub ahead of
print] PMID: 15605421
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Nestin (a marker of neural stem
cells; red flourescence) and neurofilament-M
(green flourescence) fibres were identified
innervating the infarct region of the damaged rat
heart.
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