Cardiologie d'intervention                                             

Luc Bilodeau ,  M.D

My research team's particular interests include clinical research, animal modelization and biomaterial development in interventional cardiology.  Global work aims at searching for new applications, technique refinement and implantation of new concepts for minimally invasive percutaneous treatment of coronary disease, valvulopathy, peripheral vascular disease and cardiac failure.

Actually we are working at refining coated and covered stents to prevent restenosis.  We have a research program in gene therapy for refractory angina.  We elaborate in conjunction with the medical devices industry a new generation of excimer laser to treat totally occluded arteries.  We are also working at developing percutaneous mitral annuloplasty.

Book Chapters
 
Bilodeau L, Tanguay JF, Sirois M. Restenosis in peripheral intervention. In. R.R. Heuser and M. Henry. Textbook of Peripheral Vascular Interventions. Martin Dunitz, Taylor & Francis Group plc. United Kingdom. 475-484 – 2003
 
Thierry B, Bilodeau L, Tabrizian M.  STENTS Encyclopedia of Biomaterials and Biomedical Engineering D0I:10.1081/E-EBBE 120005525.pages 1403-1411.
 
Published Articles
 
Thierry B, Merhi Y, Bilodeau L, Trépanier C, Tabrizian M. (2002) Nitinol Versus Stainless Steel Stents : Acute thrombogenicity Study in an Ex vivo Porcine Model. Biomaterials, 23:2997-3005.
 
Tuinenburg JC, Koning G, Hekking E, Desjardins C, Harel F, Bilodeau L, van Weert AW, Lespérance J, Reiber JHC JH.  One core laboratory at two international sites, is that feasible? An inter-core laboratory and intra-observer variability study. Catheter Cardiovasc Interv. 2002 Jul;56(3):333-340.
 
Thierry B, Merhi Y, Trépanier C, Bilodeau L, Yahia L'H, Tabrizian M. (2002) Blood compatibility of Nitinol compared to Stainless Steel.  SMST Proc, 285-290.
 
Stone GW, Cox DA, Babb J, Nukta D, Bilodeau L, Cannon L, Stuckey TD, Hermiller J, Cohen EA, Low R, Bailey SR, Lansky AJ, Kuntz RE. Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus containing coronary arteries. J Am Coll Cardiol. 2003 Dec 3; 42(11):2007-13.
 
Bilodeau L, Fretz E B, Taeymans Y, Koolen J, Taylor K, Hilton D J.  Novel use of a high energy excimer laser catheter for calcified and complex coronary artery lesions. Catheter Cardiovasc Inter.  Catheter Cardiovasc Interv 2004;62 :155-161.
 
Perrault LP, Jeanmart H, Bilodeau L, Lesperance J, Tanguay JF, Bouchard D, Page P, Carrier M.  Early quantitative coronary angiography of sapheneous vein grafts for coronary artery bypass grafting harvested by means of open versus endoscopic saphenectomy:  A prospective randomized trial.  J Thorac Cardiovasc Surg 2004 May;127(5):1402-7.
 
Fort S, Silber S, Lewis BS, Kornowski R, Bilodeau L, Almagor Y, van Remortel E, Morice MC, Colombo A.  “Fused-Gold” vs. “Bare” Stainless Steel NIRflex Stents of the Same Geometric Design in Diseased Native Coronary Arteries – Long term Results from the NIR TOP Study.  Submitted to Am J Cardiol (04-11-02).
 
Tanabe K, Serruys PW, Degertekin M, Guagliumi G, Grube E, Chan C, Munzel T, Belardi J, Ruzyllo W, Bilodeau L, Kelback H, Ormiston J, Dwakins K, Roy L, Strauss BH, Disco C, Koglin J, Russell ME. Chronic Arterial Responses to Polymer Controlled Paclitaxel-Eluting Stents. Circulation. 2004;109:196-200 
 
 Thierry B. Kujama P, Tkaczyk C, Winnik FM, Bilodeau L, Tabrizian M.  Delivery Plateform for Hydrophobic Drugs:  Prodrug Approach Combined with Self-Assembled Multilayers.  J Am Chem S  Accepted for publication.
 
Awaida JPS, Dupuis J, Théroux P, Pelletier G., Joyal M, deGuise P, Doucet S., Bilodeau L, Thibault B, Tanguay JF, Gallo R. Grégoire J, L'Allier P, Macle M, Nigam A.  Demographics, treatment and outcome of acute coronary syndromes:  17 years of experience in a specialized cardiac centre.  (Submitted to CMAJ).
 
Fort S, Silber S, Lewis BS, Kornowski R, Bilodeau L, Almagor Y, van Remortel E, Morice MC, Colombo A.  Fused-gold vs. bare stainless steel NIRflex Stents of the same geometric design in diseased native coronary arteries – Long term result from the NIR TOP study.  Am J Cardiol.  (submitted November 2004).
 
Ly H, Awaida JPS, Lespérance J, Bilodeau L.  Angiographic and Clinical Outcomes of polytetrafluoroethylene-covered stent use in significant coronary perforations.  Am J Cardiol 2005;95:244-246.  
 
Abstracts
 
Perrault L, Bilodeau L, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M. A prospective Randomized Angiographic Study of Open Versus Endoscopic Saphenectomy for CABG. Can. J Cardiol. Oct 2002: Abstract 191.
 
Thierry B, Merhi Y, Bilodeau L, Winnik F, Tabrizian M. “Polysaccharide Nanoscale Autoassembly on Injured Arteries”, ESB, September 2002, Spain.
 
Perrault LP, Bilodeau L, Jeanmart H, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M. A prospective Randomized Angiographic Study of Open Versus Endoscopic Saphenectomy for CABG.  Heart Surg Forum 6 (Suppl 1):S48,2003.
 
 Jeanmart H, Perrault LP, Bilodeau L, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M.  Quantitative Coronary Angiography of Saphenous Vein Grafts for CABG Harvested by Open Versus Endoscopic Saphenectomy. Can J Cardiol 19 (Suppl A)132A:2003: Abstract 2181.
 
Jeanmart H, Perrault LP, Bilodeau L, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M.  Quantitative Coronary Angiography of Saphenous Vein Grafts for CABG Harvested by Open Versus Endoscopic Saphenectomy, Research Day, Montreal Heart Institute, June 2003.
 
Jeanmart H, Perrault LP, Bilodeau L, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M.  Quantitative coronary angiography of sapheneous vein grafts for coronary artery bypass graft harvested by open versus endoscopic saphenectomy.  Clin Sci (Suppl IV) :IV-657, 2003
 
Jeanmart H, Perrault LP, Bilodeau L, Lespérance J, Tanguay JF, Bouchard D, Pagé P, Carrier M.  Quantitative coronary angiography of sapheneous vein grafts for coronary artery bypass graft harvested by open versus endoscopic saphenectomy  Circulation 108 (Suppl IV):IV-627, 2003.
 
Lasic Z, Mehran R, Nikolsky E, Negoita M, Costa R, Cox DA, Babb J, Nukta D, Bilodeau L, Cannon L, Stuckey TD, Hermiller J, Lansky A, Leon MB, Stone GW. Lennox Hill Hospital, New York City, NY. Implications and prevention of large periprocedural myocardial infarction after percutaneous intervention of diseased saphenous vein grafts and thrombotic native coronary lesions.  J Am Coll Cardiol 2004. Abstract (88-A)1155-78, Suppl A, (43).
 
Thierry B, Winnik F, Merhi Y, Bilodeau L, Tabrizian M. “Non-Viral transfection of the vasculature though self-assembled nanocoatings”, WBC, May 2004, Australia.
 
Wacinski P, Bilodeau L, Crépeau J, deGuise P, Gallo R, Ibrahim R, Joyal M, L'Allier P, Tanguay JF, Doucet S.  Drug Eluting Stents in complex coronary lesions.  Comparison of Sirolimus (Cypher) and Paclitaxel (Taxus) Stents in Clinical Practice.  Single Center experience. Munich, ESC 2004.  European Heart Journal
 
Wacinski P, Bilodeau L, Gallo R, Tanguay JF, Ibrahim R, L'Allier P, Crépeau J,  Doucet S.  Are drug eluting stents an alternative for CABG in patients with multivessel coronary artery disease or left main lesion?  Single center experience.  Washington, TCT 2004.  Am J Cardiol (TCT-469, p. 216E)
 
Wacinski P, Bilodeau L, Crépeau J, Gallo R, Ibrahim R, Tanguay JF, Doucet S.  Excimer laser 0,9 mm catheter for calcified uncrossable coronary lesions.  Washington, TCT 2004.  Am J Cardiol (TCT-92, p.42E)
 
Wacinski P, Bilodeau L, Gallo R, Ibrahim R, Crépeau J, Joyal M, deGuise P, Doucet S.  Drug eluting stents in complex coronary lesion.  Comparison of Sirolimus (Cypher) and Paclitaxel (Taxus) stents in clinical practice.  Washington, TCT 2004.  Am J Cardiol (TCT-285, p. 133E)
 
Awaida JP, Dupuis J, Théroux P, Joyal M, deGuise P, Doucet S, Bilodeau L, Tanguay JF, Gallo R, Grégoire J, L'Allier P, Macle L.  Demographics, treatment and outcome of acute coronary syndromes:  17 years of experience in a tertiary care centre.  CCS-2004 Can J Cardiol; Vol 20,  Suppl. D, page 124D # 316.
 
Ly HQ, Awaida JP, Lespérance J, Bilodeau L.  Angiographic and clinical outcomes of PTFE-covered stent use in PCI-related significant coronary perforations.  CCS-2004 Can J Cardiol; Vol 20,  Suppl. D, page 193D # 577.
 
Ramanathan K, Cantor WJ, Nguyen CM, Buller CE, Webb J, Bilodeau L, Farkouh ME, Tmychak W, Labinaz M, Fitchett D, Hochman JS, Dzavik V.  High rates of persistent cardiogenic shock despite re-establishing patency of the infarct-related artery:  A report from the Shock-2 screening log registry.  CCS-2004 Can J Cardiol; Vol 20,  Suppl. D, page 194D  # 580.